Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10433407 | Journal of Biomechanics | 2011 | 7 Pages |
Abstract
Elevated stretch magnitudes were observed along the leaflet base and coaptation line consistent with previously reported calcification patterns suggesting the higher mechanical stretch experienced by the leaflets in these regions may contribute to increased disease propensity. Transient stretch overloads were observed during diastolic closing, predominantly along the leaflet base, indicating the presence of a dynamic fluid hammer effect resulting from retrograde blood flow impacting the leaflet. We speculate the function of the leaflet base to act in cooperation with the sinuses of Valsalva to dampen the fluid hammer effect and reduce stress levels imparted on the rest of the leaflet.
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Engineering
Biomedical Engineering
Authors
Michael Weiler, Choon Hwai Yap, Kartik Balachandran, Muralidhar Padala, Ajit P. Yoganathan,