Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10433427 | Journal of Biomechanics | 2011 | 6 Pages |
Abstract
We investigated numerically the mechanism of margination of Plasmodium falciparum malaria-infected red blood cells (Pf-IRBCs) in micro-scale blood flow. Our model illustrates that continuous hydrodynamic interaction between a Pf-IRBC in the trophozoite stage (Pf-T-IRBC) and healthy red blood cells (HRBCs) results in the margination of the Pf-T-IRBC and, thus, a longer duration of contact with endothelial cells. The Pf-T-IRBC and HRBCs first form a “train”. The volume fraction of RBCs is then locally increased, to approximately 40%, and this value is maintained for a long period of time due to the formation of a long train in high-hematocrit conditions. Even in low-hematocrit conditions, the local volume fraction is instantaneously elevated to 40% and the Pf-T-IRBC can migrate to the wall. However, the short train formed in low-hematocrit conditions does not provide continuous interaction, and the Pf-T-IRBC moves back to the center of the channel.
Related Topics
Physical Sciences and Engineering
Engineering
Biomedical Engineering
Authors
Yohsuke Imai, Keita Nakaaki, Hitoshi Kondo, Takuji Ishikawa, Chwee Teck Lim, Takami Yamaguchi,