Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10434450 | Journal of Biomechanics | 2005 | 9 Pages |
Abstract
Histologically, the osteochondral defects showed bone resorption at the base and bone formation from the circumference. At 12 weeks, the macroscopically healed specimens showed fibrous cartilage formation, a minimally organized trabecular structure and increased trabecular volume fraction compared to the controls (p<0.002). The amount of cancellous, cartilagineous, and fibrous tissue and the defect size as measured in histomorphometric analysis for the three time points (4, 6 and 12 weeks) was comparable in magnitude to that predicted by finite element analysis. The simulated osteochondral healing process was not fully capable of re-establishing a hyaline-like cartilage layer. The correlation between simulation and histology allows identification of mechanical factors that appear to have a larger impact on the healing of osteochondral defects than previously considered.
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Authors
Georg N. Duda, Zully M. Maldonado, Petra Klein, Markus O.W. Heller, Justin Burns, Hermann Bail,