Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10435033 | Medical Engineering & Physics | 2015 | 9 Pages |
Abstract
Simultaneous pressure and volume measurements enable the extraction of valuable parameters for left ventricle function assessment. Cardiac MR has proven to be the most accurate method for volume estimation. Nonetheless, measuring pressure simultaneously during MRI acquisitions remains a challenge given the magnetic nature of the widely used pressure transducers. In this study we show the feasibility of simultaneous in vivo pressure-volume acquisitions with MRI using optical pressure sensors. Pressure-volume loops were calculated while inducing three inotropic states in a sheep and functional indices were extracted, using single beat loops, to characterize systolic and diastolic performance. Functional indices evolved as expected in response to positive inotropic stimuli. The end-systolic elastance, representing the contractility index, the diastolic myocardium compliance, and the cardiac work efficiency all increased when inducing inotropic state enhancement. The association of MRI and optical pressure sensors within the left ventricle successfully enabled pressure-volume loop analysis after having respective data simultaneously recorded during the experimentation without the need to move the animal between each inotropic state.
Keywords
PVAESPESVend-systolic pressure–volume relationshipend-diastolic pressure–volume relationshipEDPVRIsovolumic relaxationCWEEDVVCOESPVRMRIPotential energyeffective arterial elastanceisovolumic contractionCardiac outputleft ventricleMagnetic resonance imagingend-systolic volumestroke volumepressure–volumecardiovascular magnetic resonanceHeart rateend diastolic volumeStroke workejection fraction
Related Topics
Physical Sciences and Engineering
Engineering
Biomedical Engineering
Authors
Dima Abi-Abdallah Rodriguez, Emmanuel Durand, Ludovic de Rochefort, Younes Boudjemline, Elie Mousseaux,