Longitudinal investigation of the impact of anxiety and mood disorders in adolescence on subsequent substance use disorder onset and vice versa

► This longitudinal study examined whether emotional disorders predict SUD onset and vice versa. ► Baseline data and 4 years of follow-up were included for 627 participants. ► Anxiety and mood disorders predicted onset of SUDs. ► Social anxiety disorder predicted onset of alcohol use disorders and PTSD predicted onset of SUDs. ► SUDs did not predict emotional disorders in general but they did predict OCD onset.