The roles of anxiety and depression in connecting tic severity and functional impairment

▶ This study provides one of the largest catchments on non-treatment-seeking adults with CTD to date. ▶ Although severe tics are frequently endorsed, tic-related impairment is comparatively less common. ▶ Among individuals with CTD endorsing significant anxiety and/or depressive symptoms, the severity of tics relates strongly to impairment. ▶ Both anxious and depressive symptoms moderate the relationship between tic severity and impairment.