| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10454881 | Brain, Behavior, and Immunity | 2011 | 8 Pages |
Abstract
⺠Male subjects with PTSD had an overall pattern of under-expression of genes on monocytes (47 under-expressed versus 4 over-expressed genes). ⺠There was no transcriptional evidence of chronic inflammation in male PTSD+ subjects. ⺠In contrast, preliminary data from our pilot sample of female PTSD+ subjects showed a relatively balanced pattern of increased and decreased expression of genes and an increase in activity of pathways related to immune activation. ⺠The results indicate differential patterns of monocyte gene expression in PTSD, and are suggestive of gender dimorphism in biologic pathways activated in PTSD.
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Authors
Thomas C. Neylan, Bing Sun, Hans Rempel, Jessica Ross, Maryann Lenoci, Aoife O'Donovan, Lynn Pulliam,