| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10454987 | Brain, Behavior, and Immunity | 2011 | 8 Pages |
Abstract
⺠Lower levels of varicella-zoster virus cell-mediated immunity (VZV-CMI) explain the increased risk and severity of herpes zoster. ⺠Increasing age lowers VZV-CMI and is associated with increased risk of herpes zoster. ⺠The occurrence of major depression in older adults further lowers VZV-CMI. ⺠Severity of depressive symptoms, along with increasing age, correlate with lower levels of VZV-CMI in depressed subjects. ⺠Depression, and its severity, may add to the risk of herpes zoster in older adults.
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Authors
Michael R. Irwin, Myron J. Levin, Carmen Carrillo, Richard Olmstead, Anne Lucko, Nancy Lang, Michael J Caulfield, Adriana Weinberg, Ivan S.F. Chan, Jim Clair, Jeff G. Smith, R.D. Marchese, Heather M. Williams, Danielle J. Beck, Patricia T. McCook,