| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10455046 | Brain, Behavior, and Immunity | 2009 | 9 Pages |
Abstract
The results show a strong differential mobilisation of CD8TL subsets (RAEMÂ >Â EMÂ >Â CMÂ >Â naïve); during high intensity exercise the greatest increase was observed for RAEM CD8Tls (+450%) and the smallest for naïve cells (+84%). Similarly, CD56dim NK cells (+995%) were mobilised to a greater extent than CD56bright (+153%) NK cells. In conclusion, memory CD8TL that exhibit a high effector and tissue-migrating potential are preferentially mobilised during exercise. This finding unifies a range of independent observations regarding exercise-induced phenotypic and functional changes in circulating lymphocytes. The selective mobilisation of cytotoxic tissue-migrating subsets, both within the NK and CD8TL population, may enhance immune-surveillance during exercise.
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Authors
John P. Campbell, Natalie E. Riddell, Victoria E. Burns, Mark Turner, Jet J.C.S. Veldhuijzen van Zanten, Mark T. Drayson, Jos A. Bosch,