Neural correlates of stimulus response and stimulus outcome shifting in healthy participants and MS patients

► Two basic strategies of adaptation are shifting responses or shifting expected outcome. ► These basic processes can be studied with one physically identical design. ► In fMRI, response shifting activated premotor and parietal areas. ► Outcome shifting activated right anterior temporal cortex and right parietal regions. ► Outcome shifting also relied on the integrity of right frontal white (uncinate fascicle).