Disruption of large-scale neural networks in non-fluent/agrammatic variant primary progressive aphasia associated with frontotemporal degeneration pathology

► We examined non-fluent/agrammatic primary progressive aphasia in FTLD. ► The core clinical characteristic is slowed, effortful expression. ► This is related to impaired grammatical processing. ► Disruption of 3 large-scale neural networks contributes to naPPA expression.