Closing the gap between clinic and cage: Sensori-motor and cognitive behavioural testing regimens in neurotoxin-induced animal models of Parkinson's disease

Article ID	Journal	Published Year	Pages	File Type
10461474	Neuroscience & Biobehavioral Reviews	2012	20 Pages	PDF

Abstract

âº A review of studies using behavioural tests in toxin-based animal models of PD. âº We highlight tests to detect and measure motor- and non-motor cognition-related PD symptoms. âº Development of such tests are essential for producing transcendable treatments for PD.

Keywords

DBS mETC MFB d-cycloserine MWM MAO DCs PACAP N-methyl-d-aspartate GDNF NMDA MPTP AMPA DAT LBS 6-Hydroxydopamine EPA 6-OHDA Aβ 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine CeA l-3,4-dihydroxyphenylalanine l-DOPA SNpc α-synuclein Testing amyloid-β α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid Eicosapentaenoic acid gamma-aminobutyric acid Dopamine transporter Lewy bodies medial forebrain bundle Alzheimer's disease Parkinson's disease deep-brain stimulation substantia nigra pars compacta tyrosine hydroxylase Dopamine Behaviour mitochondrial electron transport chain Motor function glial-derived neurotrophic factor Morris water maze PPN Animal models monoamine oxidase HPA Pedunculopontine nucleus central nucleus of the amygdala hypothalamic-pituitary-adrenal GABA