Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10461514 | Neuroscience & Biobehavioral Reviews | 2012 | 17 Pages |
Abstract
⺠Mutated Na+/K+-ATPase α-isoforms give rise to neurological diseases, FHM2 and RDP. ⺠FHM2: Familial Hemiplegic Migraine type 2; RDP: Rapid-onset of Dystonia Parkinsonism. ⺠Sodium-potassium pump function is impaired in FHM2 and RDP patients. ⺠Mouse models for FHM2 and RDP do mimic certain traits of the human diseases. ⺠Mouse models are useful for dissecting the pathogenesis of FHM2 and RDP.
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Authors
Pernille Bøttger, Canan DoÄanlı, Karin Lykke-Hartmann,