Piecing together the puzzle of acetaldehyde as a neuroactive agent

Article ID	Journal	Published Year	Pages	File Type
10461565	Neuroscience & Biobehavioral Reviews	2012	27 Pages	PDF

Abstract

âº The review summarizes decades of studies on acetaldehyde as ethanol metabolite. âº The review summarizes decades of studies on acetaldehyde as stand-alone compound. âº The review deals with all the so-called still unresolved questions on acetaldehyde. âº The review puts a great emphasis on central vs peripheral acetaldehyde's effects. âº The review suggests that many of central ethanol's effects depend on acetaldehyde.

Keywords

A-type potassium current DMS SNR aCSF ACBC Conditioned taste preference VTA i.c.v.DOPAC DRL NTS DDTC VLs 4MP ALDH PBN i.g.Salsolinol LAP AcbSh ARH i.v.BSTL THP CYP2E1 CTP 4-methylpyrazole CPP ADH BEC CyP ERK SNC ATZ CTA ASOS diethyl dithiocarbamate ANT dihydroxyphenylacetaldehyde CPA IRT i.p.Acb CeA MAPK Mitogen activated protein kinases Ventral pallidum dorsomedial striatum ventrolateral striatum Substantia Nigra, pars reticulata aldehyde dehydrogenase Aminotriazole Ethanol Conditioned place avoidance acetaldehyde ANA Alcohol preferring rats Alcohol dehydrogenase Conditioned taste aversion Tetrahydropapaveroline conditioned place preference Intracerebroventricular administration intraperitoneal administration intragastric administration Intravenous administration substantia nigra, pars compacta Dopamine dihydroxyphenylacetic acid Superior colliculus BBB blood brain barrier Cytochrome P450 extracellular signal regulated kinase DOPAL blood ethanol concentration artificial cerebrospinal fluid MEK i.c.ventral tegmental area knock out fixed ratio wild type Nucleus accumbens nucleus accumbens core nucleus accumbens shell parabrachial nucleus bed nucleus of the stria terminalis nucleus of the solitary tract arcuate nucleus of the hypothalamus central nucleus of the amygdala paraventricular nucleus of the hypothalamus Taste reactivity HPV Catalase HAp