Article ID Journal Published Year Pages File Type
10461599 Neuroscience & Biobehavioral Reviews 2011 9 Pages PDF
Abstract
▶ Parkinson's disease patients have high incidences of affective disorders. ▶ l-DOPA treatment does not reliably improve affective symptoms. ▶ l-DOPA is taken up by NE and 5-HT neurons and released as a false neurotransmitter. ▶ l-DOPA may worsen or induce anxiety and depression by perturbing NE and 5-HT systems.
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Life Sciences Neuroscience Behavioral Neuroscience
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Potential mechanisms underlying anxiety and depression in Parkinson's disease: Consequences of l-DOPA treatment
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