Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10461603 | Neuroscience & Biobehavioral Reviews | 2011 | 13 Pages |
Abstract
The present review summarizes recent findings in BDNF-mutant mice, which have been controversially discussed as models of depression and anxiety. It furthermore illustrates the potential of environment to serve as naturalistic stressor with the potential to modulate the phenotype in wildtype and mutant mice. Moreover, environment may exert protective effects by regulating BDNF levels as attributed to “environmental enrichment”. The effect of this beneficial condition will also be discussed with regard to probable “curative/therapeutic” approaches.
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Authors
Sabine Chourbaji, Christiane Brandwein, Peter Gass,