Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10461799 | Neuroscience & Biobehavioral Reviews | 2013 | 11 Pages |
Abstract
⺠We developed a novel rat task to assess visuospatial priming, a measure of competitive information processing with relevance to Tourette syndrome. ⺠Rats exhibited robust negative priming (NP) in our task. ⺠Amphetamine had rate-dependent effects on NP, disrupting NP in high NP rats and enhancing NP in low NP rats. ⺠Our task may constitute a valuable novel tool for investigating the neural bases of NP deficits in TS and other neuropsychiatric disorders.
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Authors
Nurith Amitai, Martin Weber, Neal R. Swerdlow, Richard F. Sharp, Michelle R. Breier, Adam L. Halberstadt, Jared W. Young,