Article ID Journal Published Year Pages File Type
10461800 Neuroscience & Biobehavioral Reviews 2013 7 Pages PDF
Abstract
► We review the cross-species utility of prepulse inhibtion (PPI) as an operational measure of sensorimotor gating. ► PPI deficits in Tourette Syndrome (TS) and in other neurodevelopmental brain disorders are discussed. ► The neurobiological regulation of PPI by forebrain circuitry implicated in the pathophysiology of TS is described. ► A conceptual linkage is noted between deficient sensorimotor gating and intrusive sensory phenomena now recognized as a core feature of TS. ► An update of recent findings relevant to the relationship of PPI to TS is provided.
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