Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10461800 | Neuroscience & Biobehavioral Reviews | 2013 | 7 Pages |
Abstract
⺠We review the cross-species utility of prepulse inhibtion (PPI) as an operational measure of sensorimotor gating. ⺠PPI deficits in Tourette Syndrome (TS) and in other neurodevelopmental brain disorders are discussed. ⺠The neurobiological regulation of PPI by forebrain circuitry implicated in the pathophysiology of TS is described. ⺠A conceptual linkage is noted between deficient sensorimotor gating and intrusive sensory phenomena now recognized as a core feature of TS. ⺠An update of recent findings relevant to the relationship of PPI to TS is provided.
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Authors
Neal R. Swerdlow,