Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia

These results provide the first evidence that disinhibition in PD is related to fronto-striatal grey matter atrophy. Our study adds support to the hypothesis that impulsivity in PD is not solely mediated by dopaminergic medication effects, but that fronto-striatal structural abnormalities contribute to impulsive behaviours in these patients.