Medial temporal lobe contributions to cued retrieval of items and contexts

► A prediction of the Binding of Items and Contexts (or BIC) model was tested. ► Contributions of MTL structures to cued recall of items and contexts were examined. ► Parahippocampal cortex supports successful retrieval of contexts from item cues. ► Perirhinal cortex supports item and context retrieval from associated cues. ► Hippocampus supports flexible content-general relational memory retrieval.