Age-related differences in memory and executive functions in healthy APOE ɛ4 carriers: The contribution of individual differences in prefrontal volumes and systolic blood pressure

► Studied: effects of genetic and physiological vascular risk on brain and cognition. ► Examined links of age, systolic BP, brain volumes, and cognition with path analysis. ► Found smaller prefrontal volumes in APOE ɛ4 carriers with elevated systolic BP. ► Observed reduced cognitive performance in ɛ4 carriers with high-normal BP. ► APOE ɛ4 and physiological vascular risk act in synergy to reduce performance.