Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10466443 | Neuropsychologia | 2010 | 10 Pages |
Abstract
We hypothesize that faulty executive control is the primary deficit, reflected by the reduced N2 component in the mutation carriers. To compensate for this deficit, mutation carriers change their strategy of speed-accuracy trade-off, in order to dampen the excitability of their lateral motor system. Disease progression might prevent symptomatic PD patients from using this compensatory mechanism, leading to increased disinhibition of their lateral motor system.
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Behavioral Neuroscience
Authors
Rolf Verleger, Johann Hagenah, Manuel WeiÃ, Thomas Ewers, Ilse Heberlein, Peter P. Pramstaller, Hartwig R. Siebner, Christine Klein,