Vaccine innovation, translational research and the management of knowledge accumulation

► The impact of increased funding supply or improved market demand on vaccine innovation is mediated by problem solving processes. ► These problem solving processes typically involve cumulative learning across a series of increasingly complex models. ► When experimental models are missing additional co-ordination may be needed to integrate fragmented research findings. ► Managed co-ordination rather than researcher driven enquiry drove the successful development of poliomyelitis vaccines.