Quality-of-Life-Adjusted Hazard of Death: A Formulation of the Quality-Adjusted Life-Years Model of Use in Benefit-Risk Assessment

This result leads to a new representation of the linear QALY model in terms of hazard rate functions and allows utilities obtained by using standard methods involving trade-offs of life duration to be translated into thresholds of tolerated mortality risk during a short period of time, thereby avoiding direct trade-offs using small probabilities of events during the study, which is known to lead to bias and variability.