Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10509496 | Drug and Alcohol Dependence | 2013 | 6 Pages |
Abstract
Findings confirm that injection naltrexone produces extinction of drug-seeking behavior after episodes of opiate use. Adequate dosage appears important, as low-dose naltrexone resembled the placebo group; opiate positive urines were likely to be followed by dropout from treatment. The observation of high treatment retention among naltrexone-treated patients who do not test the blockade, suggests naltrexone may also exert direct effects on opiate-taking behavior that do not depend on extinction, perhaps by attenuating craving or normalizing dysregulated hedonic or neuroendocrine systems.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Maria A. Sullivan, Adam Bisaga, John J. Mariani, Andrew Glass, Frances R. Levin, Sandra D. Comer, Edward V. Nunes,