Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10509887 | Drug and Alcohol Dependence | 2005 | 9 Pages |
Abstract
Opioid- and cocaine-dependent participants (NÂ =Â 140) were randomly assigned to one of the following in a 12-week clinical trial: LAAM (30, 30, 39Â mg/MWF) with contingency management (CM) procedures (LC); LAAM (30, 30, 39Â mg/MWF) without CM (LY); LAAM (100, 100, 130Â mg/MWF) with CM (HC); LAAM (100, 100, 130Â mg/MWF) without CM (HY). Urine samples were collected thrice-weekly. In CM, each urine negative for both opioids and cocaine resulted in a voucher worth a certain monetary value that increased for consecutively drug-free urines. Subjects not assigned to CM received vouchers according to a yoked schedule. Vouchers were exchanged for mutually agreed upon goods and services. Groups generally did not differ on retention and baseline characteristics. Overall opioid use was least in the HC and HY groups; opioid use decreased most rapidly over time in the HC group relative to the HY, LC and LY groups. Overall cocaine use was least in the HC group relative to the HY, LC, and LY groups; cocaine use decreased over time most rapidly in the HC and LY groups. Abstinence from both was greatest in the HC group. Opioid withdrawal symptoms decreased most rapidly in the high-dose groups relative to the low-dose groups. These results suggest that an efficacious maintenance dose is necessary for contingencies to be effective in facilitating both opioid and cocaine abstinence.
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Authors
Alison Oliveto, James Poling, Kevin A. Sevarino, Kishorchandra R. Gonsai, Elinore F. McCance-Katz, Susan M. Stine, Thomas R. Kosten,