Article ID Journal Published Year Pages File Type
10533027 Analytical Biochemistry 2013 6 Pages PDF
Abstract
A novel TiO2/CdS nanocomposite was prepared and used to fabricate an electrochemiluminescence (ECL) biosensor for the detection of cancer cells for the first time. The nanocomposite exhibited a strong cathodic ECL signal. Folic acid for targeting cell membranes was bound to a TiO2/CdS/3-aminopropyltriethoxysilane film, and specific recognition of folic acid to targeting cells was achieved, leading to a significant decrease in ECL intensity. The decrease in ECL signal was logarithmically related to the cell concentration in the range of 150-9600 cells mL-1. The ECL biosensor could provide a sensitive, selective, and convenient approach for early and accurate detection of cancer cells.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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