Article ID Journal Published Year Pages File Type
10536813 Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2012 9 Pages PDF
Abstract
► P. falciparum (Pf) adenylosuccinate synthetase (AdSS) is a homodimeric enzyme. ► Dimer interface of PfAdSS is distinct from E. coli and mouse AdSS. ► Enzyme has a preponderance of positively charged residues at dimer interface. ► Crystal structure shows additional electron density around interface cysteines. ► Stability studies on interface cysteine mutants suggest role for thiolate anion.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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