Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10536813 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2012 | 9 Pages |
Abstract
⺠P. falciparum (Pf) adenylosuccinate synthetase (AdSS) is a homodimeric enzyme. ⺠Dimer interface of PfAdSS is distinct from E. coli and mouse AdSS. ⺠Enzyme has a preponderance of positively charged residues at dimer interface. ⺠Crystal structure shows additional electron density around interface cysteines. ⺠Stability studies on interface cysteine mutants suggest role for thiolate anion.
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Sonali Mehrotra, Mylarappa B.Ningappa, Jayalakshmi Raman, Ranjith P. Anand, Hemalatha Balaram,