Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

► Discovery (along with Profs. Hershko and Rose) of the ubiquitin proteolytic system. ► Ubiquitin-mediated degradation of transcription factors. ► Regulation of the ubiquitin system components by ubiquitination and degradation. ► Recognition and targeting signals for ubiquitination and proteasomal degradation. ► History of the research area of intracellular proteolysis.