| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10536889 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2012 | 16 Pages |
Abstract
⺠Cathepsin L in secretory vesicles participates in the biosynthesis of peptide neurotransmitters and hormones. ⺠Cathepsin B produces neurotoxic β-amyloid in secretory vesicles and represents a new drug target for Alzheimer's disease. ⺠The secretory vesicle proteome indicates the protein environment that supports cathepsins L and B in the production of active peptides. ⺠Cysteine cathepsins possess novel biological functions in secretory vesicles for health and disease.
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Authors
Vivian Hook, Lydiane Funkelstein, Jill Wegrzyn, Steven Bark, Mark Kindy, Gregory Hook,