| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10536891 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2012 | 10 Pages |
Abstract
⺠We discuss the emerging role of the caspase-8 in cellular survival and activation. ⺠Caspase-8 homodimer is pro-apoptotic; the heterodimer with FLIPL is pro-survival. ⺠Control of RIPK1 activity is an essential function of caspase-8. ⺠Heterodimer in complex with FADD and RIPK1 activates NF-κB, only if FLIPL is cleaved. ⺠Further cleavage of the caspase-8 inter-subunit linker turns the heterodimer pro-apoptotic.
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Authors
Bram J. van Raam, Guy S. Salvesen,