| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10536892 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2012 | 10 Pages |
Abstract
⺠Lysosomal proteases contribute to intracellular and pericellular tumor proteolysis. ⺠Pericellular tumor proteolysis occurs at focal sites on the cell surface. ⺠Pericellular proteolysis is increased by an acidic tumor microenvironment. ⺠Tumor and tumor-associated cells mediate proteolysis in the microenvironment. ⺠Tumor proteolysis can be localized in real-time by live-cell imaging techniques.
Keywords
MT-MMPMAMEdye-quencheduPARAPuPARuPAMMPPAI-1GPiIDCPHEFAPDCISExtracellular pHFunctional imagingTIMPRBMreconstituted basement membrane3D cultureurokinase plasminogen activatormatrix metalloproteinasePlasminogen activator inhibitor-1Matrix metalloproteinase inhibitorsTissue inhibitors of metalloproteinasesTumor microenvironmentLysosomal proteasesFibroblast activation proteinDuctal carcinoma in situInvasive ductal carcinomaglycosylphosphatidylinositolUrokinase plasminogen activator receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jennifer M. Rothberg, Mansoureh Sameni, Kamiar Moin, Bonnie F. Sloane,