| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10536893 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2012 | 13 Pages |
Abstract
⺠Osteoarthritis is characterised by degradation of cartilage extracellular matrix. ⺠Collagen is degraded by matrix metalloproteinases such as MMP-13. ⺠Aggrecan is degraded by related ADAMTS metalloproteinases. ⺠Less abundant cartilage components are degraded by a variety of proteinases. ⺠Factors such as inflammation and mechanical damage stimulate enzyme expression.
Keywords
APCADAMTSuPAHIF-2αECMsirtuin 1IGDIGFBPFGF-2Wisp-1PACE4GLAHDACERKhypoxia-inducible factor 2αRUNX2tPAIGFγ-CarboxyglutamateMMPSirt1FAPαaggrecanaseOsteoarthritisa disintegrin and metalloproteinase with thrombospondin motifsParCited2TIMPfibroblast growth factor 2Runt-related transcription factor 2CartilageInsulin-like growth factorTissue-type plasminogen activatorurokinase-type plasminogen activatorExtracellular matrixmatrix metalloproteinaseTissue inhibitor of metalloproteinaseshistone deacetylaseIGF binding proteinActivated protein CFibroblast activation protein αProteinaseproprotein convertasecollagenaseprotease-activated receptor
Related Topics
Physical Sciences and Engineering
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Authors
Linda Troeberg, Hideaki Nagase,