| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10536899 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2012 | 12 Pages |
Abstract
⺠The Trypanosoma cruzi Genome Project predicts peptidases from all catalytic classes. ⺠However, the chymotrypsin and pepsin families seem to be absent. ⺠The major cysteine proteinase, cruzipain, is a virulence factor for the parasite. ⺠Two S9 serine peptidases are also potential targets for chemotherapy. ⺠T. cruzi has two M32 peptidases, absent so far in all other eukaryotic genomes.
Keywords
PeptidasesGP63TLCKNHMecE-64BOCPCDPNAcpsSPSC-TN-benzyloxycarbonylAPsp-NitroaniliderespectivelyTrypanosoma cruziChagas diseasephosphatidylethanolamineMetalloproteinasesMHCmajor histocompatibility complexProgrammed cell deathMPspolymerase chain reactionPCRcysteine proteinasesSerine proteinasesCruzipain
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Vanina E. Alvarez, Gabriela T. Niemirowicz, Juan J. Cazzulo,