| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537000 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 7 Pages |
Abstract
⺠The fibrinolytic fragment of clotting factor Xa (Xa), Xa33/13, was found in plasma. ⺠A source of Xa33/13 in plasma is from the Xa-antithrombin (XaAT) complex. ⺠Conversion of Xa to Xa33/13 occurs at least 10-fold faster in complex with AT. ⺠XaAT accelerates plasma clot lysis and plasmin generation by tPA better than FXa. ⺠A novel function for XaAT was identified that links coagulation to fibrinolysis.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Kimberley Talbot, Scott C. Meixner, Edward L.G. Pryzdial,