Insights into the molecular mechanism of protein native-like aggregation upon glycation

Article ID	Journal	Published Year	Pages	File Type
10537003	Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics	2013	47 Pages	PDF

Abstract

âº A model mechanism for Cyt c native-like aggregation upon glycation is proposed. âº Methylglyoxal glycation reduces Cyt c conformational stability. âº The molecular mechanism relies on protein native-like aggregate stabilization. âº Monolayer experiments show a thermodynamically and kinetically favored process.

Keywords

1,2-Dimyristoyl-sn-glycero-3-phospho-l-serine dMPC MGH TOF DMPS GdnHCl ACN MAGE AIC SEC CID 1,2-dimyristoyl-sn-glycero-3-phosphocholine Acetonitrile Conformational disease collision induced dissociation Lipid monolayer time of flight Age cytochrome c MALDI Methylglyoxal Advanced glycation end-product Akaike Information Criteria Guanidinium hydrochloride Hydroimidazolone Size exclusion chromatography Glycation

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

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Insights into the molecular mechanism of protein native-like aggregation upon glycation

Authors

Luis M.A. Oliveira, Ricardo A. Gomes, Dennis Yang, Sarah R. Dennison, Carlos FamÃlia, Ana Lages, Ana V. Coelho, Regina M. Murphy, David A. Phoenix, Alexandre Quintas,