| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537010 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 12 Pages |
Abstract
⺠Protein kinases are critical enzymes in signal transduction networks. ⺠Virtual screening identified bi-thiazole-2,2â²-diamines as potential JNK inhibitors. ⺠JNK was inhibited by the compound JD123, but not a related compound JD124. ⺠JD123 inhibited the related kinase p38γ; broader screening showed Aktβ inhibition. ⺠Bi-thiazoles can act as a new protein kinase inhibitory scaffold.
Keywords
EGFRDcxAMP-PNPERKGSTGSHJIPMEFPVDFSTD NMRJnkJNK-interacting proteinc-Jun N-terminal kinaseDMSOMAPKMAPK kinaseMKKp38 MAPKPKB/AKTadenosine 5′-(β,γ-imido)triphosphatedimethyl sulphoxideKineticsmurine embryonic fibroblastChemical inhibitorProtein kinaseprotein kinase Bmitogen-activated protein kinasePolyvinylidene fluorideGlutathioneglutathione S-transferaseEpidermal growth factor receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Kevin R.W. Ngoei, Dominic C.H. Ng, Paul R. Gooley, David P. Fairlie, Martin J. Stoermer, Marie A. Bogoyevitch,