| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537014 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 8 Pages |
Abstract
⺠The inner-work mechanism of base release in IAG-nucleoside hydrolase was illuminated by MD simulations. ⺠The key residues promoting the base release have been characterized. ⺠The helix-to-coil change of loop 2 was revealed and it was in agreement with the XRD's structures. ⺠Our simulations confirmed the key switches to control the loop's open/closed state and found His247 is a novel controller.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Nanhao Chen, Hu Ge, Jun Xu, Zexing Cao, Ruibo Wu,