| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537016 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 13 Pages |
Abstract
⺠Frataxin protein of an extreme psychrophilic organism was solved at 1.45 Ã
. ⺠The thermodynamic stability of this frataxin variant is strongly modulated by pH. ⺠B-factors show a differential flexibility in comparison to mesophilic homolog. ⺠The protonation state of His residues alters the protein motions. ⺠Electrostatic interactions may be involved in FXN adaptation to cold environments.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ernesto A. Roman, Santiago E. Faraj, Alexandra Cousido-Siah, André Mitschler, Alberto Podjarny, Javier Santos,