Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10537032 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2011 | 8 Pages |
Abstract
⺠First crystal structure of transialidase-like lectin iTS in complex with carbohydrate. ⺠The sialyl moiety is not visible in density, while lactose remains bound. ⺠iTS is confirmed to retain a residual sialidase activity by enzyme kinetics assays. ⺠iTS is able to bind sialylated glycoproteins as measured by surface plasmon resonance. ⺠The molecular details explain the lectin behavior of this trypanosomal protein family.
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Analytical Chemistry
Authors
Pablo Oppezzo, Gonzalo Obal, MartÃn A. Baraibar, Otto Pritsch, Pedro M. Alzari, Alejandro Buschiazzo,