Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms

Article ID	Journal	Published Year	Pages	File Type
10537120	Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics	2015	12 Pages	PDF

Keywords

PAH Tyrosine hydroxylase deficiency THD tetrahydrobiopterin BH4 DSF tph2 PKU phenylketonuria l-DOPA Parkinson's disease Enzyme stabilization tyrosine hydroxylase Dopamine synthesis Pharmacological chaperone Differential scanning fluorimetry Phenylalanine hydroxylase Iron coordination

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

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Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms

Authors

Magnus Hole, Jarl Underhaug, Hector Diez, Ming Ying, Ãsmund Kjendseth RÃ¸hr, Ana Jorge-Finnigan, NoÃ¨lia FernÃ ndez-Castillo, Angels GarcÃa-Cazorla, K. Kristoffer Andersson, Knut Teigen, Aurora Martinez,