| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537141 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 16 Pages |
Abstract
⺠Structure-function analysis was carried out with fungal P450s. ⺠Key determinants governing interactions with substrates, inhibitors and redox partners were elucidated. ⺠A generalized molecular model of crucial sites was created on the basis of the bacterial CYP102A1 template. ⺠Biotechnological exploitation of the topological data in medicinal and commercial areas is discussed.
Keywords
ICZNADPH-cytochrome P450 oxidoreductaseSYBYLFCZMMFFKCZCHARMmBenzoheterocyclesPCZTDMCTZPosaconazoleVCZCoMFAMerck Molecular Force FieldSRSTDFMICCPRItraconazoleIsoquinolinesBenzopyronesBifonazoleStructure–function analysiscomparative molecular field analysisTriadimenolMinimal inhibitory concentrationDiniconazolesubstrate recognition siteTriadimefonCytochrome P450Chemistry at HARvard Macromolecular MechanicsFluconazoleMolecular Operating EnvironmentMolecular modelingPolycyclic aromatic hydrocarbonsPAHsvoriconazoleMOEKetoconazoleChromanesclotrimazole
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Peter Hlavica,