| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537147 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 7 Pages |
Abstract
⺠B. anthracis DHFR is effectively inhibited by dihydrophthalazine inhibitors. ⺠Derivations at the chiral center of these inhibitors markedly affect the potency. ⺠Enzyme and whole cell inhibition and crystallography indicate best derivations. ⺠In silico calculations highlight role of enantiomeric energy differences. ⺠Potency is maximized with S-phenyl or S-isobutenyl groups on the phthalazine.
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Authors
Christina R. Bourne, Nancy Wakeham, Baskar Nammalwar, Vladimir Tseitin, Philip C. Bourne, Esther W. Barrow, Shankari Mylvaganam, Kal Ramnarayan, Richard A. Bunce, K. Darrell Berlin, William W. Barrow,