Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10537150 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 16 Pages |
Abstract
⺠Phosphorylation of protein phosphatase-1 (PP1) inhibitor-2 (I2) activates PP1-I2. ⺠The intrinsically disordered I2 phosphorylation region was modeled using NMR data. ⺠Molecular dynamics revealed phosphorylation induced structural alterations. ⺠I2 phosphorylation increased frequencies three initial steps of PP1-I2 activation. ⺠I2 phosphorylation-induced rapid movements were transmitted to the PP1 active site.
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Physical Sciences and Engineering
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Analytical Chemistry
Authors
John F. Cannon,