| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537158 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 11 Pages |
Abstract
⺠We report new platelet-derived chemokine heterodimers detected by mass spectrometry ⺠Several strong heterodimers were observed, including CXCL4/CXCL12 heterodimer ⺠The stability of CXCL4/CXCL12 heterodimer was confirmed using MD simulations ⺠In vivo relevance of this heterodimer was confirmed by Co-IP from human platelets ⺠Results strongly support future functional studies of chemokine heterodimers
Keywords
PDBHeterodimerGAGGPCRRMSDACNESI-MSAcetonitrileElectrospray Ionization Mass Spectrometryroot-mean-square deviationNMRSPRSurface plasmon resonanceMolecular dynamicsCo-IPMass spectrometry (MS)Nuclear magnetic resonance spectroscopyCo-ImmunoprecipitationMolecular weightWestern blotProtein Data BankPlateletChemokinesGlycosaminoglycanG protein-coupled receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
James Carlson, Sarah A. Baxter, Didier Dréau, Irina V. Nesmelova,