| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537160 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 9 Pages |
Abstract
⺠Mass spectrometry quantified hierarchy of tryptic sites in proinsulin derivatives. ⺠Km, kcat., and kcat./Km were obtained for tryptic sites in proinsulin derivatives. ⺠K29-T30 tryptic cleavage shielded in proinsulin/insulin, not in di-arginyl insulin. ⺠B/C site variation of human and buffalo proinsulin causes tryptic regioselectivity.
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Authors
Qurra-tul-Ann Afza Gardner, Hooria Younas, Muhammad Akhtar,