| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537188 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2013 | 6 Pages |
Abstract
⺠ROS are implicated as mediators of cell-signaling responses by targeting the PTPs. ⺠The exact identity of the oxidants that inactivate the PTPs is unknown. ⺠We show that the hydroxyl radical is capable of inactivating the PTPs. ⺠We also show that hydroxyl radical is a kinetically more efficient oxidant than H2O2. ⺠Hydroxyl radical is a more physiologically relevant oxidant for PTP inactivation.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Fan-Guo Meng, Zhong-Yin Zhang,