| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537373 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2011 | 11 Pages |
Abstract
⺠Four CcP mutants (H52D, H52E, H52Q, H52N) have been characterized. ⺠The mutants retain between 0.01 and 0.4% of the catalytic activity of CcP. ⺠The CcP(H52Q)-H2O2 reaction is the slowest yet observed for any CcP mutant. ⺠The endogenous decay of Compound I for the mutants is distinct from that of wtCcP. ⺠The rates of Compound I formation and HCN binding are correlated in 9 CcP mutants.
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Authors
Miriam C. Foshay, Lidia B. Vitello, James E. Erman,