| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537378 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2011 | 9 Pages |
Abstract
⺠The neurotransmitter serotonin (5-HT) suppresses amyloid fibril growth of alpha-synuclein (AS). ⺠5-HT binds to intermediate aggregates of alpha-synuclein, not to monomeric AS. Consequently, 5-HT does not influence initial steps of amyloidogenesis. ⺠5-HT promotes the accumulation of partially structured, SDS-resistant “on pathway” aggregates of AS. ⺠The C-terminal region of AS is essential for a charge dependent interaction. ⺠“On pathway” and “off-pathway” aggregations of AS might mechanistically overlap.
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Authors
S. Fabio Falsone, Gerd Leitinger, Anita Karner, Andreas J. Kungl, Simone Kosol, Roberto Cappai, Klaus Zangger,