| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10537384 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2011 | 9 Pages |
Abstract
⺠5-phenoxy-2,3-pentadienylamine inactivates Arthrobacter globiformis amine oxidase (AGAO). ⺠6-phenyl-2,3-hexadienylamine inactivates AGAO. ⺠Crystal structures of AGAO attached to inactivators reveal mechanism of action. ⺠IC50 values reveal inhibition potency and suggest selectivity in AGAO inactivation. âºStructural framework to guide the design of selective mechanism-based inhibitors.
Keywords
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Karin Ernberg, Bo Zhong, Kristin Ko, Larry Miller, Yen Hoang le Nguyen, Lawrence M. Sayre, J. Mitchell Guss, Irene Lee,